Sunday, May 14, 2017
Wednesday, May 10, 2017
Monday, March 20, 2017
A study of recipient related predictors of success in oocyte donation program
http://www.jhrsonline.org/article.asp?issn=0974-1208;year=2012;volume=5;issue=3;spage=252;epage=257;aulast=Gupta
Abstract
Abstract
Background:
Oocyte donation is an invaluable therapy for couples with impending or
complete ovarian failure. In addition, oocyte donation affords a
scientific opportunity to study the unique biologic participation of the
uterus in the process of human embryo implantation. Aim: To
identify the recipient variables that may have a significant impact on
pregnancy outcome in order to optimize results of an oocyte donation
program. Design and Settings: A prospective study conducted from
March 1, 2010 to March 31, 2011 at a private tertiary care IVF Clinic.
Materials and methods A total of 270 recipients resulting in embryo
transfer as a result of oocyte donation were enrolled. Clinical and
Ongoing pregnancy rates, Implantation rates were calculated according to
different age groups, Endometrial thickness, Indication, Day and number
of embryos transferred. Data was evaluated as chi square analyses with
comparative significance determined at P <.05. Results:
In recipients less than 40 years of age, higher ongoing pregnancy and
implantation rates (41.9% and 24.6%) were seen as compared to recipients
above 40 years (21.8% and 13.18%) respectively. Pregnancy and
implantation rates increased with increasing endometrial thickness but
the difference was not statistically significant. A higher ongoing
pregnancy rate (40.9% vs.28.8%) and implantation rate (23% vs.19.6%) was
demonstrated with Day 3 embryo transfer compared to Day 2 transfer. Conclusion:
A declining endometrial receptivity may result in lower implantation
and pregnancy rates in recipients above the age of 40 years, more
pronounced after the age of 45 years. An endometrial thickness of >8
mm is considered ideal before transfer. Transfer of two selected embryos
on day 3 yields a favorable pregnancy outcome with reduced multiple
pregnancy rates. Recipient's age above 45 years has negative impact on
pregnancy outcome whereas embryo transfers on Day 3 yields better
pregnancy
Available from: http://www.jhrsonline.org/text.asp?2012/5/3/252/106336
Sunday, March 19, 2017
How a test tube baby is born?
What
is a test tube baby?
Test tube baby is a baby conceived
through In vitro fertilization, also called IVF in brief. In vitro means the biological
process is carried outside body. In this
technique woman’s eggs are fertilized with husband’s sperms outside body in
laboratory in a petridish. The embryos formed in the process are transferred
into the womb of woman which results in pregnancy.
Who
needs In Vitro Fertilization or IVF
A couple may need IVF when they are not
able to have baby by natural method or with simple treatment. Some couples are
advised to undergo IVF without any prior simple or other treatments like in cases:
When husband’s sperm count or quality is
below specific limits,
Women
who are not able to produce eggs or with both fallopian tubes blocked or
defects in the uterus or severe endometriosis .These couple can have baby with IVF.
The
Process of making Test Tube baby
IVF treatment should be taken under
supervision of IVF expert Doctors. Before a couple undergoes IVF blood test are
done. The treatment starts with the onset of menstruation and lasts for 15 days
approximately or 10-14 days prior to menses depending upon the protocol of
treatment.
Step 1: Women undergoing treatment receives
daily injections for 8-12 days to produce multiple eggs. Injections can be
given by trained nurses or even the couple can be trained to administer
injections themselves with simple pen devices similar to insulin pens.
Step 2: When the size of eggs is
appropriate which is confirmed by ultrasound, she undergoes a procedure called Ovum
Pick up in which eggs are taken out from her body with a special needle under
anesthesia. She can go back home after 4-6 hrs and continue her routine
activities. The eggs are inseminated with husband’s semen in Embryology lab
under highly controlled environment by Embryologist.
Step 3: Embryos are formed after fertilization.
One or two embryos are transferred in to the womb of wife after 2-5days.This is
a painless procedure in which no anesthesia is required. Surplus embryos can be
frozen in lab for future treatment. That completes the treatment of one cycle.
Woman is advised to continue certain
medications at home. Pregnancy is confirmed by a blood or urine tests 2 weeks
later.
Success of treatment depends on various
factors including women’s age, functional capacity of her ovaries and reason of
infertility.
Certain
facts about IVF
There are no known long-term harmful
effects of fertility medications on woman. Children born with this technique
are as normal as naturally born babies.
A woman whether housewife or in job, can
continue her daily routine household activities, travelling during or after treatment.
There is no need of bed rest.
Egg/Embryo
Donation, Donor semen insemination
For women with advanced age or women of
younger age whose ovaries have stopped functioning due to certain medical or
surgical problems can achieve pregnancy through IVF with Egg donation. If there
are no sperms in husband’s semen Donor’s semen can be used. In case of problem
with both husband and wife, Embryo donation is the possibility.
Surrogacy
When a woman carries pregnancy and
delivers child for another couple it is called surrogacy .Pregnancy is
conceived through IVF procedure in which couple’s eggs and sperms are used .Surrogacy
is done only in case when wife is not able to carry pregnancy due defects in her
uterus or some other serious medical condition.
Do
You Know?
Out of every 100 couples, 10-15 couples
need some kind of treatment for infertility.
World’s 1st IVF baby was born in 1978 in England and in just 35 years, more
than 5 million babies are born worldwide through IVF.
Subscribe to:
Posts (Atom)